Pharmacological targeting of endoplasmic reticulum stress signaling in cancer
AH Schönthal - Biochemical pharmacology, 2013 - Elsevier
The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …
[PDF][PDF] Targeting endoplasmic reticulum stress for cancer therapy
AH Schonthal - Frontiers in Bioscience-Scholar, 2012 - article.imrpress.com
Introduction 3. The yin-yang principle of ER stress 4. ER stress as an Achilles' heel of cancer
5. Pharmacological targeting of ER stress 5.1. Thapsigargin and tunicamycin 5.2 …
5. Pharmacological targeting of ER stress 5.1. Thapsigargin and tunicamycin 5.2 …
Combination of tunicamycin with anticancer drugs synergistically enhances their toxicity in multidrug-resistant human ovarian cystadenocarcinoma cells
Background The pharmacologic modulatory effects of the antibiotic, tunicamycin (TM), on
multidrug-resistant human UWOV2 ovarian cancer cells are reported. The UWOV2 cell line …
multidrug-resistant human UWOV2 ovarian cancer cells are reported. The UWOV2 cell line …
Tunicamycin-induced ER stress in breast cancer cells neither expresses GRP78 on the surface nor secretes it into the media
JE Serrano-Negrón, Z Zhang, AP Rivera-Ruiz… - …, 2018 - academic.oup.com
GRP78 (an Mr 78 kDa calcium dependent glucose binding protein) is located in ER lumen. It
functions as ER chaperone and translocates proteins for glycosylation at the asparagine …
functions as ER chaperone and translocates proteins for glycosylation at the asparagine …
Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression
EJ Lim, J Heo, YH Kim - Apoptosis, 2015 - Springer
Tunicamycin (TN), one of the endoplasmic reticulum stress inducers, has been reported to
inhibit tumor cell growth and exhibit anticarcinogenic activity. However, the mechanism by …
inhibit tumor cell growth and exhibit anticarcinogenic activity. However, the mechanism by …
In vitro modulation of doxorubicin and docetaxel antitumoral activity by methyl-β-cyclodextrin
PY Grosse, F Bressolle, F **uet - European Journal of Cancer, 1998 - Elsevier
Methyl-β-cyclodextrin (MEBCD) was investigated for its eVect on the antitumoral activity of
various antineoplastic agents (doxorubicin (DOX), docetaxel (DXL), 5-fluorouracil (5-FU) …
various antineoplastic agents (doxorubicin (DOX), docetaxel (DXL), 5-fluorouracil (5-FU) …
Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response
A H. Schonthal, T C. Chen, F M. Hofman… - Current …, 2011 - benthamdirect.com
The endoplasmic reticulum (ER) stress response represents a cellular “yin-yang” process,
where low to moderate activity is cell protective and supports chemoresistance (yang), but …
where low to moderate activity is cell protective and supports chemoresistance (yang), but …
[PDF][PDF] The expression of P-gp in leukemia cells is associated with cross-resistance to protein N-glycosylation inhibitor tunicamycin
L Pavlikova, M Seres, D Imrichova, M Hano… - Gen. Physiol …, 2016 - researchgate.net
In P-gp-positive cell variants obtained from L1210 cells either by selection with vincristine
(L1210/R) or by transfection with the human gene encoding P-gp (L1210/T), we have …
(L1210/R) or by transfection with the human gene encoding P-gp (L1210/T), we have …
N-Glycans influence the in vitro adhesive and invasive behaviour of three metastatic cell lines
D Bironaite, JM Nesland, H Dalen, B Risberg, M Bryne - Tumor biology, 2000 - karger.com
Alterations in cellular glycosylation may play a key role in metastatic behaviour of tumour
cells. We studied three metastatic cell lines, LOX (malignant melanoma), FEMX (malignant …
cells. We studied three metastatic cell lines, LOX (malignant melanoma), FEMX (malignant …
Cytotoxicity determination without photochemical artifacts
M Heuser, M Kopun, W Rittgen, C Granzow - Cancer letters, 2005 - Elsevier
A study was performed to improve cytotoxicity determinations by eliminating flavin-mediated
photosensitization from tests with KB cells, NCI-H69 cells, P-glycoprotein expressing KBC5 …
photosensitization from tests with KB cells, NCI-H69 cells, P-glycoprotein expressing KBC5 …