Extracellular vesicles as a next-generation drug delivery platform
Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …
RNA delivery by extracellular vesicles in mammalian cells and its applications
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …
A review on exosomes application in clinical trials: perspective, questions, and challenges
Background Exosomes are progressively known as significant mediators of cell-to-cell
communication. They convey active biomolecules to target cells and have vital functions in …
communication. They convey active biomolecules to target cells and have vital functions in …
[HTML][HTML] Extracellular vesicles as drug delivery systems: Why and how?
OM Elsharkasy, JZ Nordin, DW Hagey… - Advanced drug delivery …, 2020 - Elsevier
Over the past decades, a multitude of synthetic drug delivery systems has been developed
and introduced to the market. However, applications of such systems are limited due to …
and introduced to the market. However, applications of such systems are limited due to …
Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic
stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the …
stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the …
Exosomes, a new star for targeted delivery
H Chen, L Wang, X Zeng, H Schwarz… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing
numerous biological molecules including nucleic acids, proteins and lipids, which are …
numerous biological molecules including nucleic acids, proteins and lipids, which are …
Extracellular vesicles for drug delivery
P Vader, EA Mol, G Pasterkamp… - Advanced drug delivery …, 2016 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an
endogenous mechanism for intercellular communication. Since the discovery that EVs are …
endogenous mechanism for intercellular communication. Since the discovery that EVs are …
Biodistribution of extracellular vesicles following administration into animals: A systematic review
In recent years, attention has turned to examining the biodistribution of EVs in recipient
animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a …
animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a …
Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization
L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …
the attention of researchers worldwide, encouraging the field to rapidly develop improved …
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
DE Murphy, OG de Jong, M Brouwer… - … & molecular medicine, 2019 - nature.com
Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …