Predicting multiple conformations via sequence clustering and AlphaFold2
Abstract AlphaFold2 (ref.) has revolutionized structural biology by accurately predicting
single structures of proteins. However, a protein's biological function often depends on …
single structures of proteins. However, a protein's biological function often depends on …
Circadian oscillators: around the transcription–translation feedback loop and on to output
From cyanobacteria to mammals, organisms have evolved timing mechanisms to adapt to
environmental changes in order to optimize survival and improve fitness. To anticipate these …
environmental changes in order to optimize survival and improve fitness. To anticipate these …
Circadian rhythms in cyanobacteria
SE Cohen, SS Golden - Microbiology and Molecular Biology …, 2015 - Am Soc Microbiol
Life on earth is subject to daily and predictable fluctuations in light intensity, temperature,
and humidity created by rotation of the earth. Circadian rhythms, generated by a circadian …
and humidity created by rotation of the earth. Circadian rhythms, generated by a circadian …
AlphaFold2 fails to predict protein fold switching
AlphaFold2 has revolutionized protein structure prediction by leveraging sequence
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
Prediction of multiple conformational states by combining sequence clustering with AlphaFold2
Abstract AlphaFold2 (AF2) has revolutionized structural biology by accurately predicting
single structures of proteins and protein-protein complexes. However, biological function is …
single structures of proteins and protein-protein complexes. However, biological function is …
Reconstitution of an intact clock reveals mechanisms of circadian timekee**
INTRODUCTION Circadian clocks provide an internal representation of local time inside
cells and control the timing of gene expression in anticipation of sunrise and sunset. In …
cells and control the timing of gene expression in anticipation of sunrise and sunset. In …
CyanoGate: a modular cloning suite for engineering cyanobacteria based on the plant MoClo syntax
R Vasudevan, GAR Gale, AA Schiavon… - Plant …, 2019 - academic.oup.com
Recent advances in synthetic biology research have been underpinned by an exponential
increase in available genomic information and a proliferation of advanced DNA assembly …
increase in available genomic information and a proliferation of advanced DNA assembly …
Extant fold-switching proteins are widespread
A central tenet of biology is that globular proteins have a unique 3D structure under
physiological conditions. Recent work has challenged this notion by demonstrating that …
physiological conditions. Recent work has challenged this notion by demonstrating that …
Structural basis of the day-night transition in a bacterial circadian clock
R Tseng, NF Goularte, A Chavan, J Luu, SE Cohen… - Science, 2017 - science.org
Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in
synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational …
synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational …
Timing the day: what makes bacterial clocks tick?
CH Johnson, C Zhao, Y Xu, T Mori - Nature Reviews Microbiology, 2017 - nature.com
Chronobiological studies of prokaryotic organisms have generally lagged far behind the
study of endogenous circadian clocks in eukaryotes, in which such systems are essentially …
study of endogenous circadian clocks in eukaryotes, in which such systems are essentially …