Alzheimer's disease (AD) is a progressive neurodegenerative disorder that eventually leads
to dementia and death of the patient. Despite the enormous amounts of resources and …

Introduction–AD, the most common form of dementia, has a multifactorial etiology, and the
current therapy (AChEIs and memantine) is unable to interrupt its progress and fatal …

Rhubarb is a well‐known traditional Chinese medicine; it has been used in China for
thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived …

Rhein is one of the anthraquinones components of Rheum. It shows excellent clinical
efficacy and is widely used in the management of several disease conditions including …

Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which
main clinical manifestations are cognitive dysfunction, memory impairment and mental …

Aim: Simultaneous modulation of several key targets of the pathological network of
Alzheimer's disease (AD) is being increasingly pursued as a promising option to fill the …

Alzheimer's disease remains largely unknown, and currently there is no complete cure for
the disease. New synthetic approaches have been developed to create multi-target agents …

Starting from six potential hits identified in a virtual screening campaign directed to a cryptic
pocket of BACE-1, at the edge of the catalytic cleft, we have synthesized and evaluated six …

Background Alzheimer's disease (AD) is characterized by a polyetiological origin. Despite
the global burden of AD and the advances made in AD drug research and development, the …

Aβ (1-42) peptide is a neurotoxic agent strongly associated with the etiology of Alzheimer's
disease (AD). Current treatments are still of very low effectiveness, and deaths from AD are …