Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Individuals with SARS-CoV-2 infection can develop symptoms that persist well beyond the
acute phase of COVID-19 or emerge after the acute phase, lasting for weeks or months after …

Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in
humans. The current high levels of population immunity, due to prior infection and/or …

Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

The world continues to contend with COVID-19, fueled by the emergence of viral variants. At
the same time, a subset of convalescent individuals continues to experience persistent and …

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor
clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin …

Background Bone marrow mesenchymal stem cell (BM-MSC)-derived extracellular vesicles
(ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs …