Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism
mediated by eukaryotic cells is relatively well studied, much less is known about sulfur …

Biothiols, which have a close network of generation and metabolic pathways among them,
are essential reactive sulfur species (RSS) in the cells and play vital roles in human …

Synthesis of cysteine as a product of the transsulfuration pathway can be viewed as part of
methionine or homocysteine degradation, with cysteine being the vehicle for sulfur …

The mammalian liver tightly regulates its free cysteine pool, and intracellular cysteine in rat
liver is maintained between 20 and 100 nmol/g even when sulfur amino acid intakes are …

We present a colorimetric and ratiometric fluorescent probe Cy–N3 that exhibits a selective
response to H2S. The probe employs a near-infrared cyanine as a fluorophore, and is …

Serine is generally classified as a nutritionally nonessential (dispensable) amino acid, but
metabolically, serine is indispensible and plays an essential role in several cellular …

As a kind of bioactive sulfur species, biothiols (Cys, Hcy, and GSH) play an irreplaceable
role in regulating the redox balance of life processes. Because of their similar chemical …