Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Endoplasmic reticulum (ER) stress is triggered upon the interference with oxidative protein
folding that aims to produce fully folded, disulfide-bonded and glycosylated proteins …

The molecular mechanisms leading to saliva secretion are largely established, but factors
that underlie secretory hypofunction, specifically related to the autoimmune disease …

It is well established that distinct cell metabolic alterations strongly contribute to the
modulation of innate and adaptive immune responses. In the past decade the term …

The endoplasmic reticulum (ER) is a dynamic structure, playing multiple roles including
calcium storage, protein synthesis and lipid metabolism. During cellular stress, variations in …

Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases
such as primary Sjogren's syndrome (pSS), however, the mechanism (s) is unknown. Our …

The present study aimed to identify the possible protective effect of diacerein (DIA) on
gentamicin (GNT)‐induced parotid toxicity in rats. DIA was administered in the presence and …

The current research aimed to examine the ameliorative role of febuxostat (FEB), a highly
potent xanthine oxidase inhibitor, against 5-fluorouracil (5-FU)-induced parotid salivary …

Cadmium (Cd) is a potent environmental pollutant that causes functional and structural
damage to the salivary glands. Tempol (TEM) has powerful antioxidant activity that can …

This study investigated the roles of transient receptor potential (TRP) ankyrin-1 (TRPA1) and
TRP vanilloid-3 (TRPV3) in regulating endoplasmic reticulum stress (ERS) and cytotoxicity …