Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Heart failure is a complex syndrome responsible for high rates of death and hospitalization.
Ischemic heart disease is one of the most frequent causes of heart failure and it is normally …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

The fundamental mechanisms governing the perpetuation of atrial fibrillation (AF), the most
common arrhythmia seen in clinical practice, are poorly understood, which explains in part …

Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Cardiac fibroblasts help maintain the normal architecture of the healthy heart and are
responsible for scar formation and the healing response to pathological insults. Various …

Alzheimer's disease (AD) and cerebrovascular diseases share common vascular risk factors
that have disastrous effects on cerebrovascular regulation. Endothelial cells, lining inner …

Previous studies have found that oxidative stress is the negative reaction of the imbalance
between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and …