An important challenge during the COVID-19 pandemic has been to understand
asymptomatic disease and the extent to which this may be a source of transmission. As …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some …

The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …

Although alterations in myeloid cells have been observed in COVID-19, the specific
underlying mechanisms are not completely understood. Here, we examine the function of …

During pregnancy the maternal–fetal interface plays vital roles in fetal development. Its
disruption is frequently found in pregnancy complications. Recent studies show increased …

Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated
activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells …

Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of
protective immunity to future variants, but we lack insights into immune responses before or …

Blood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon
(IFN) signalling, but it is not known whether there are biological differences in their …

Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-
19 patients, but the timing and organs affected vary among reports. Here, we reveal the …