Background The pharmaceutical industry is in the midst of a productivity crisis and rates of
translation from bench to bedside are dismal. Patients are being let down by the current …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

" Антихрупкость"—книга уникальная: она рассказывает о ключевом свойстве людей,
систем, о свойстве, у которого до сих пор не было названия. В мире, где царит …

Antifragile is a standalone book in Nassim Nicholas Taleb's landmark Incerto series, an
investigation of opacity, luck, uncertainty, probability, human error, risk, and decision-making …

Background Drug development is currently hampered by high attrition rates; many
developed treatments fail during clinical testing. Part of the attrition may be due to low …

Objective To examine the role of explainability in machine learning for healthcare (MLHC),
and its necessity and significance with respect to effective and ethical MLHC application …

Technological innovations are seen as means to optimize the efficient and clean use of vital
resources in social-biological-economic systems. However, partial theoretical perspectives …

Newly discovered true (non-null) associations often have inflated effects compared with the
true effect sizes. I discuss here the main reasons for this inflation. First, theoretical …

Although much progress is being made in understanding the molecular pathways in the
placenta that are involved in the pathophysiology of pregnancy-related disorders, a …

Advances in genomics have led to mounting expectations in regard to their impact on health
care and disease prevention. In light of this fact, a comprehensive research agenda is …