Molecular physiology of water balance

MA Knepper, TH Kwon, S Nielsen - New England Journal of …, 2015 - Mass Medical Soc
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Map** protein post-translational modifications with mass spectrometry

ES Witze, WM Old, KA Resing, NG Ahn - Nature methods, 2007 - nature.com
Post-translational modifications of proteins control many biological processes, and
examining their diversity is critical for understanding mechanisms of cell regulation. Mass …

Large-scale proteomics and phosphoproteomics of urinary exosomes

PA Gonzales, T Pisitkun, JD Hoffert… - Journal of the …, 2009 - journals.lww.com
Normal human urine contains large numbers of exosomes, which are 40-to 100-nm vesicles
that originate as the internal vesicles in multivesicular bodies from every renal epithelial cell …

[HTML][HTML] Molecular mechanisms governing aquaporin relocalisation

A Markou, L Unger, M Abir-Awan, A Saadallah… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …

[HTML][HTML] Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury

H Zhou, T Pisitkun, A Aponte, PST Yuen, JD Hoffert… - Kidney international, 2006 - Elsevier
Urinary exosomes containing apical membrane and intracellular fluid are normally secreted
into the urine from all nephron segments, and may carry protein markers of renal dysfunction …

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

TC Moyer, KM Clutario, BG Lambrus… - Journal of Cell …, 2015 - rupress.org
Centriole duplication occurs once per cell cycle in order to maintain control of centrosome
number and ensure genome integrity. Polo-like kinase 4 (Plk4) is a master regulator of …

Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

M Boone, PMT Deen - Pflügers Archiv-European Journal of Physiology, 2008 - Springer
To prevent dehydration, terrestrial animals and humans have developed a sensitive and
versatile system to maintain their water homeostasis. In states of hypernatremia or …

[KÖNYV][B] Mammalian transient receptor potential (TRP) cation channels

B Nilius, V Flockerzi - 2014 - Springer
When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases

ETB Olesen, RA Fenton - Nature Reviews Nephrology, 2021 - nature.com
Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment

HB Moeller, S Rittig, RA Fenton - Endocrine reviews, 2013 - academic.oup.com
The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a
pivotal role in maintaining body water balance. The channel is regulated by the peptide …