Advances in bladder cancer biology and therapy
The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …
generation sequencing has identified the genes most mutated in bladder cancer. This …
BRD4 and Cancer: going beyond transcriptional regulation
B Donati, E Lorenzini, A Ciarrocchi - Molecular cancer, 2018 - Springer
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”
The World Health Organization (WHO) central nervous system tumor classification
represents the primary source of updates on diagnostic classes, grades and criteria [17] …
represents the primary source of updates on diagnostic classes, grades and criteria [17] …
TERT—regulation and roles in cancer formation
M Dratwa, B Wysoczańska, P Łacina, T Kubik… - Frontiers in …, 2020 - frontiersin.org
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …
complex plays a key role in cancer formation by telomere dependent or independent …
Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk
Key challenges for human genetics, precision medicine and evolutionary biology include
deciphering the regulatory code of gene expression and understanding the transcriptional …
deciphering the regulatory code of gene expression and understanding the transcriptional …
Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies
J Zhou, Q Ji, Q Li - Journal of Experimental & Clinical Cancer Research, 2021 - Springer
Cetuximab and panitumumab are monoclonal antibodies (mAbs) against epidermal growth
factor receptor (EGFR) that are effective agents for metastatic colorectal cancer (mCRC) …
factor receptor (EGFR) that are effective agents for metastatic colorectal cancer (mCRC) …
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …
the driver mutations conferring clonal advantage and the mutational processes generating …
Regulation of human telomerase in homeostasis and disease
CM Roake, SE Artandi - Nature reviews Molecular cell biology, 2020 - nature.com
Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …
Biologic and clinical perspectives on thyroid cancer
JA Fagin, SA Wells Jr - New England Journal of Medicine, 2016 - Mass Medical Soc
Biologic and Clinical Perspectives on Thyroid Cancer | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …
main content The New England Journal of Medicine homepage Advanced Search SEARCH …
Non-coding driver mutations in human cancer
Tumour formation involves random mutagenic events and positive evolutionary selection
acting on a subset of such events, referred to as driver mutations. A decade of careful …
acting on a subset of such events, referred to as driver mutations. A decade of careful …