Bacteria have to cope with oxidative stress caused by distinct Reactive Oxygen Species
(ROS), derived not only from normal aerobic metabolism but also from oxidants present in …

Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …

Infections have been a major cause of disease throughout the history of humans on earth.
With the introduction of antibiotics, it was thought that infections had been conquered …

In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Oxidative stress, through the production of reactive oxygen species, is a natural
consequence of aerobic metabolism. Escherichia coli has several major regulators activated …

In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response
regulators. The generation of dangerous radicals by oxygen and iron is the basis for this …

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous
metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction …

Campylobacter jejuni and C. coli are recognised as the leading causes of bacterial
foodborne diarrhoeal disease throughout the development world. While most foodborne …

The ferric uptake regulator (Fur) protein, as originally described in Escherichia coli, is an iron-
sensing repressor that controls the expression of genes for siderophore biosynthesis and …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …