The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action

T Isa, E Marquez-Legorreta, S Grillner, EK Scott - Current Biology, 2021 - cell.com
The superior colliculus, or tectum in the case of non-mammalian vertebrates, is a part of the
brain that registers events in the surrounding space, often through vision and hearing, but …

The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery

SE Grogans, E Bliss-Moreau, KA Buss, LA Clark… - Neuroscience & …, 2023 - Elsevier
Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …

AAV-mediated anterograde transsynaptic tagging: map** corticocollicular input-defined neural pathways for defense behaviors

B Zingg, X Chou, Z Zhang, L Mesik, F Liang, HW Tao… - Neuron, 2017 - cell.com
To decipher neural circuits underlying brain functions, viral tracers are widely applied to map
input and output connectivity of neuronal populations. Despite the successful application of …

A synaptic threshold mechanism for computing escape decisions

DA Evans, AV Stempel, R Vale, S Ruehle, Y Lefler… - Nature, 2018 - nature.com
Esca** from imminent danger is an instinctive behaviour that is fundamental for survival,
and requires the classification of sensory stimuli as harmless or threatening. The absence of …

Feature detection by retinal ganglion cells

D Kerschensteiner - Annual review of vision science, 2022 - annualreviews.org
Retinal circuits transform the pixel representation of photoreceptors into the feature
representations of ganglion cells, whose axons transmit these representations to the brain …

Organization of the inputs and outputs of the mouse superior colliculus

NL Benavidez, MS Bienkowski, M Zhu… - Nature …, 2021 - nature.com
The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of
cognitive and sensorimotor behaviors. However, it remains unclear how descending cortical …

Defensive responses: Behaviour, the brain and the body

YT Tseng, B Schaefke, P Wei, L Wang - Nature Reviews Neuroscience, 2023 - nature.com
Most animals live under constant threat from predators, and predation has been a major
selective force in sha** animal behaviour. Nevertheless, defence responses against …

Vision guides selection of freeze or flight defense strategies in mice

G De Franceschi, T Vivattanasarn, AB Saleem… - Current biology, 2016 - cell.com
In prey species such as mice, avoidance of predators is key to survival and drives instinctual
behaviors like freeze or flight [1, 2]. Sensory signals guide the selection of appropriate …

Architecture, function, and assembly of the mouse visual system

TA Seabrook, TJ Burbridge, MC Crair… - Annual review of …, 2017 - annualreviews.org
Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

[HTML][HTML] A central alarm system that gates multi-sensory innate threat cues to the amygdala

SJ Kang, S Liu, M Ye, DI Kim, GM Pao, BA Copits… - Cell reports, 2022 - cell.com
Perception of threats is essential for survival. Previous findings suggest that parallel
pathways independently relay innate threat signals from different sensory modalities to …