Mammalian Krüppel-like factors in health and diseases
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …
processes that include proliferation, differentiation, growth, development, survival, and …
The pathobiology of splicing
Ninety‐four percent of human genes are discontinuous, such that segments expressed as
mRNA are contained within exons and separated by intervening segments, called introns …
mRNA are contained within exons and separated by intervening segments, called introns …
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance
INTRODUCTION A central tenet of the clonal selection theory (CST), the current cornerstone
of adaptive immunity, states that naïve T cells are selected on the basis of specificity to …
of adaptive immunity, states that naïve T cells are selected on the basis of specificity to …
A global role for EKLF in definitive and primitive erythropoiesis
D Hodge, E Coghill, J Keys, T Maguire, B Hartmann… - Blood, 2006 - ashpublications.org
Erythroid Kruppel-like factor (EKLF, KLF1) plays an important role in definitive erythropoiesis
and β-globin gene regulation but failure to rectify lethal fetal anemia upon correction of …
and β-globin gene regulation but failure to rectify lethal fetal anemia upon correction of …
Two sides of the same coin: the roles of KLF6 in physiology and pathophysiology
The Krüppel-like factors (KLFs) family of proteins control several key biological processes
that include proliferation, differentiation, metabolism, apoptosis and inflammation …
that include proliferation, differentiation, metabolism, apoptosis and inflammation …
A Germline DNA Polymorphism Enhances Alternative Splicing of the KLF6 Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk
Prostate cancer is a leading and increasingly prevalent cause of cancer death in men.
Whereas family history of disease is one of the strongest prostate cancer risk factors and …
Whereas family history of disease is one of the strongest prostate cancer risk factors and …
Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1
Preadipocyte differentiation occurs during distinct periods of human development and is a
key determinant of body mass. Transcriptional events underlying adipogenesis continue to …
key determinant of body mass. Transcriptional events underlying adipogenesis continue to …
Zinc and cancer: implications for LIV-1 in breast cancer
BJ Grattan, HC Freake - Nutrients, 2012 - mdpi.com
Zinc is a trace mineral which is vital for the functioning of numerous cellular processes, is
critical for growth, and may play an important role in cancer etiology and outcome. The …
critical for growth, and may play an important role in cancer etiology and outcome. The …
Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype …
A recent discovery of death-from-cancer signature genes identifies potential markers
predicting the high likelihood of treatment failure in cancer patients. This knowledge …
predicting the high likelihood of treatment failure in cancer patients. This knowledge …
KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3
KLF6 (Kruppel-like factor 6) is a zinc finger transcription factor and a tumor suppressor that is
frequently mutated in prostate cancer. KLF6 suppresses tumor growth and induces …
frequently mutated in prostate cancer. KLF6 suppresses tumor growth and induces …