DNA double-strand breaks (DSBs) are one of the main types of damage induced by ionizing
radiations. Free DNA ends that are not correctly repaired can be engaged in pathways …

Activation-induced cytidine deaminase (AID) is required for somatic hypermutation and
immunoglobulin class switching in activated B cells. Because AID has no known target-site …

Primary mediastinal large B-cell lymphoma (PMBCL) is an aggressive non-Hodgkin
lymphoma that displays phenotypic and genotypic similarity to Hodgkin lymphoma and …

To better define the significance of proliferation centers (PCs), the morphological hallmark of
chronic lymphocytic leukemia (CLL), lymph node biopsies taken from 183 patients were …

Cancer cells are defective in DNA repair, so they experience increased DNA strand breaks,
genome instability, gene mutagenesis, and tumorigenicity; however, multiple classic DNA …

The Artemis gene encodes a DNA nuclease that plays important roles in non-homologous
end-joining (NHEJ), a major double-strand break (DSB) repair pathway in mammalian cells …

Introduction: Onset and progression of malignant tumors is a multistep process including a
variety of gross chromosomal and specific genes' deregulation. Among oncogenes that are …

Background Lamin A (LMNA) is a component of the nuclear lamina and is mutated in
several human diseases, including Emery-Dreifuss muscular dystrophy (EDMD; OMIM ID# …

Nuclear localization influences the expression of certain genes. Chromosomal
rearrangements can reposition genes in the nucleus and thus could impact the expression …