Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells.
The mitochondria form highly organized networks, in which their outer and inner membrane …

Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial
role in sustaining the growth and survival of cancer cells. A central function of mitochondria …

Significance: Mitochondrial function is central to a wide range of biological processes in
health and disease and there is considerable interest in develo** small molecules that are …

PET myocardial perfusion imaging (MPI) is increasingly being used for noninvasive
detection and evaluation of coronary artery disease. However, the widespread use of PET …

PET with 11C-acetate (11C-ACE) has a high sensitivity for detection of prostate cancer and
several other cancers that are poorly detected with 18F-FDG. However, the short half-life …

Apoptosis, or programmed cell death, is involved in numerous human conditions including
neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of …

Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding
imaging modality, thanks to the availability of compact medical cyclotrons and automated …

Mitochondrial membrane potential (Δ Ψ m) is a universal selective indicator of mitochondrial
function and is known to play a central role in many human pathologies, such as diabetes …