Applications of isothermal titration calorimetry–the research and technical developments from 2011 to 2015

RJ Falconer - Journal of Molecular Recognition, 2016 - Wiley Online Library
Isothermal titration calorimetry is a widely used biophysical technique for studying the
formation or dissociation of molecular complexes. Over the last 5 years, much work has …

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

MF Osborn, AH Coles, A Biscans… - Nucleic acids …, 2019 - academic.oup.com
Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing
its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue …

In vitro cytotoxicity and interaction of noscapine with human serum albumin: Effect on structure and esterase activity of HSA

N Maurya, JK Maurya, UK Singh, R Dohare… - Molecular …, 2019 - ACS Publications
Noscapine is effective to inhibit cellular proliferation and induced apoptosis in nonsmall cell,
lung, breast, lymphoma, and prostate cancer. It also shows good efficiency to skin cancer …

Spectroscopic studies of binding interactions of 2-chloroethylphenyl sulphide with bovine serum albumin

AJ Rahman, L Kaur, M Pathak, A Singh… - Journal of Molecular …, 2021 - Elsevier
Sulphur mustard is a lethal chemical warfare agent, known for its vesicant or blistering action
on skin and mucous membrane. 2-chloroethylphenyl sulphide (CEPS) is a simulant of …

Esterase activity and conformational changes of bovine serum albumin toward interaction with mephedrone: Spectroscopic and computational studies

R Patel, N Maurya, MUD Parray… - Journal of Molecular …, 2018 - Wiley Online Library
The present work is a brief overview of the effect of psychostimulant drug mephedrone
hydrochloride (4MMC) on a transport protein, bovine serum albumin (BSA). The binding …

Interplay of multiple interaction forces: binding of norfloxacin to human serum albumin

BK Paul, N Ghosh, S Mukherjee - The Journal of Physical …, 2015 - ACS Publications
Herein, the binding interaction of a potential chemotherapeutic antibacterial drug norfloxacin
(NOF) with a serum transport protein, human serum albumin (HSA), is investigated. The …

Mechanistic insight into the amyloid fibrillation inhibition of hen egg white lysozyme by three different bile acids

NA Jamuna, A Kamalakshan… - The Journal of …, 2023 - ACS Publications
Amyloid aggregation of protein is linked to many neurodegenerative diseases. Identification
of small molecules capable of targeting amyloidogenic proteins has gained significant …

Effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability and esterase activity of human serum albumin

M ud din Parray, MUH Mir, N Dohare, N Maurya… - Journal of Molecular …, 2018 - Elsevier
The binding effect of gemini surfactant, hexanediyl-α, ω-bis-(N-(2-hydroxyethyl)–N-
methylhexadecylammonium bromide)(16-6-16 MEA) and its monomeric counterpart N-(2 …

Binding interaction of pharmaceutical drug captopril with calf thymus DNA: a multispectroscopic and molecular docking study

A Mukherjee, B Singh - Journal of Luminescence, 2017 - Elsevier
Exploring the binding interaction of drug molecule with calf thymus DNA turn out to be a
dynamic field of research at the interface between biological science and medicinal …

Deciphering the binding site and mechanism of new methylene blue with serum albumins: A multispectroscopic and computational investigation

P Manivel, P Marimuthu, M Ilanchelian - Spectrochimica Acta Part A …, 2023 - Elsevier
Herein, the interaction mechanism of new methylene blue (NMB) with human serum albumin
(HSA) and bovine serum albumin (BSA) was carefully investigated both experimentally and …