After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Chromosomal phase separation is involved in a broad spectrum of chromosome
organization and functional processes. Nonetheless, the intricacy of this process has left its …

Molecular self-assembly offers a 'bottom-up'route to fabrication with subnanometre precision
of complex structures from simple components. DNA has proved to be a versatile building …

We demonstrate the ability to engineer complex shapes that twist and curve at the
nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to …

Mechanical deformations of DNA such as bending are ubiquitous and have been implicated
in diverse cellular functions. However, the lack of high-throughput tools to measure the …

CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an NGG
protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the …

Cooperative binding of transcription factors (TFs) to promoters and other regulatory regions
is essential for precise gene expression. The classical model of cooperativity requires direct …

In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9
searches millions of DNA base pairs to locate a 20-nucleotide, guide RNA-complementary …

The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to
their broad clinical application. Here we develop a magnetic nucleic acid delivery system …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …