After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Molecular self-assembly offers a 'bottom-up'route to fabrication with subnanometre precision
of complex structures from simple components. DNA has proved to be a versatile building …

We demonstrate the ability to engineer complex shapes that twist and curve at the
nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to …

Mechanical deformations of DNA such as bending are ubiquitous and have been implicated
in diverse cellular functions. However, the lack of high-throughput tools to measure the …

In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9
searches millions of DNA base pairs to locate a 20-nucleotide, guide RNA-complementary …

Cooperative binding of transcription factors (TFs) to promoters and other regulatory regions
is essential for precise gene expression. The classical model of cooperativity requires direct …

The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to
their broad clinical application. Here we develop a magnetic nucleic acid delivery system …

Elucidating the population dynamics of correlated electron-hole pairs (bound excitons) in
semiconducting quantum dots (QDs) is key for develo** our fundamental understanding of …

Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …