Tuberculous meningitis: progress and remaining questions

J Huynh, J Donovan, NH Phu, HDT Nghia… - The Lancet …, 2022 - thelancet.com
Tuberculous meningitis is a devastating brain infection that is caused by Mycobacterium
tuberculosis and is notoriously difficult to diagnose and treat. New technologies …

Intensified antituberculosis therapy in adults with tuberculous meningitis

AD Heemskerk, ND Bang, NTH Mai… - … England Journal of …, 2016 - Mass Medical Soc
Background Tuberculous meningitis is often lethal. Early antituberculosis treatment and
adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients …

Advancing the chemotherapy of tuberculous meningitis: a consensus view

S Wasserman, J Donovan, E Kestelyn… - The Lancet Infectious …, 2025 - thelancet.com
Tuberculous meningitis causes death or disability in approximately 50% of affected
individuals and kills approximately 78 200 adults every year. Antimicrobial treatment is …

Clinical standards for drug-susceptible TB in children and adolescents

SS Chiang, SM Graham, HS Schaaf… - … of Tuberculosis and …, 2023 - ingentaconnect.com
BACKGROUND: These clinical standards aim to provide guidance for diagnosis, treatment,
and management of drug-susceptible TB in children and adolescents. METHODS: Fifty-two …

Predictions of bedaquiline central nervous system exposure in patients with tuberculosis meningitis using physiologically based pharmacokinetic modeling

K Mehta, P Balazki, PH van der Graaf, T Guo… - Clinical …, 2024 - Springer
Abstract Background and Objective The use of bedaquiline as a treatment option for drug-
resistant tuberculosis meningitis (TBM) is of interest to address the increased prevalence of …

Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study

Y Feng, Y Xu, Y Yang, G Yi, H Su, H Chen… - Frontiers in Public …, 2023 - frontiersin.org
Introduction There is a high incidence of both smoking and tuberculosis (TB) in China. This
study examined the risk factors for severe pulmonary TB (PTB) and positive tubercle bacilli …

Cerebrospinal fluid AFB smear in adults with tuberculous meningitis: a systematic review and diagnostic test accuracy meta-analysis

AM Stadelman, K Ssebambulidde, A Buller, L Tugume… - Tuberculosis, 2022 - Elsevier
Abstract Background Cerebrospinal fluid (CSF) Ziehl–Neelsen acid-fast bacilli (AFB) smear
is a rapid, cheap, widely available test for tuberculous meningitis (TBM). Yet, reported test …

Comparative diagnostic utility of metagenomic next‐generation sequencing, GeneXpert, modified Ziehl–Neelsen staining, and culture using cerebrospinal fluid for …

Y Chen, Y Wang, X Liu, W Li, H Fu, X Liu… - Journal of Clinical …, 2022 - Wiley Online Library
Background Early diagnosis of tuberculosis meningitis (TBM) remains a great challenge
during clinical practice. The diagnostic efficacies of cerebrospinal fluid (CSF)‐based …

Clinical presentation, management, and outcome of suspected central nervous system infections in Indonesia: a prospective cohort study

K Maharani, S Dian, AR Ganiem, D Imran, R Estiasari… - Infection, 2024 - Springer
Background Little is known about the etiology, clinical presentation, management, and
outcome of central nervous system (CNS) infections in Indonesia, a country with a high …

A study of risk factors for tuberculous meningitis among patients with tuberculosis in China: an analysis of data between 2012 and 2019

M Huang, Y Ma, X Ji, H Jiang, F Liu, N Chu… - Frontiers in Public …, 2023 - frontiersin.org
Purpose The present study aimed to explore the risk factors for tuberculous meningitis (TBM)
among patients with tuberculosis (TB). Methods This retrospective study was conducted on …