The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological
processes including proliferation, cell cycle control, growth, and survival; common across all …

Ras proteins are classical members of small GTPases that function as molecular switches by
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …

Ras proteins are small GTPases, cycling between inactive GDP-bound and active GTP-
bound states. Through these switches they regulate signaling that controls cell growth and …

The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A
number of observations suggest that Ras is laterally organized within the cell membrane …

Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a
valid strategy for antineoplastic intervention. Upon activation, ERK dimerize, which is …

Post-translational modifications (PTMs) play a key role in numerous cellular processes by
directly affecting structure, dynamics and interaction networks of target proteins. Despite …

The Orai1–STIM1 current undergoes slow Ca2+-dependent inactivation (SCDI) mediated by
the binding of SARAF to STIM1. Here we report the use of SCDI by SARAF as a probe of the …

Myosins are among the most fascinating enzymes in biology. As extremely allosteric
chemomechanical molecular machines, myosins are involved in myriad pivotal cellular …

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream
of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that …

Oncogenes can alter metabolism by changing the balance between anabolic and catabolic
processes. However, how oncogenes regulate tumor cell biomass remains poorly …