Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

The derivation of tissue-specific stem cells from human induced pluripotent stem cells
(iPSCs) would have broad reaching implications for regenerative medicine. Here, we report …

Abstract p53 is an attractive therapeutic target in oncology because its tumour-suppressor
activity can be stimulated to eradicate tumour cells. Inhibiting the p53–MDM2 interaction is a …

Perinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and
morbidity in infants and young children. Therapeutic opportunities are very limited for …

The tumour suppressor p53 is known to prevent cancer progression by inhibiting
proliferation and inducing apoptosis of tumour cells. Slug, an invasion promoter, exerts its …

The severe acute respiratory syndrome (SARS) pandemic in Toronto resulted in a large
number of autopsies on its victims. We describe the pulmonary pathology of patients who …

Specific protein-protein interactions are involved in a large number of cellular processes and
are mainly mediated by structurally and functionally defined domains. Here we report that …

The p53 protein is related by sequence homology and function to the products of two other
genes, p63 and p73, that each encode several isoforms. We and others have discovered …