Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …
tissue and cell functions and significant increases in the risks of various aging-related …
VEGF in signaling and disease: beyond discovery and development
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …
understanding of vasculogenesis and angiogenesis during development and physiological …
Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities
PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
KL Pennington, MM DeAngelis - Eye and vision, 2016 - Springer
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation
M Hata, EMMA Andriessen, M Hata, R Diaz-Marin… - Science, 2023 - science.org
Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …
[HTML][HTML] Macrophages and lipid metabolism
A Remmerie, CL Scott - Cellular immunology, 2018 - Elsevier
Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …
Age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …
Age-related macular degeneration: genetics and biology coming together
Genetic and genomic studies have enhanced our understanding of complex
neurodegenerative diseases that exert a devastating impact on individuals and society. One …
neurodegenerative diseases that exert a devastating impact on individuals and society. One …
Metabolism of stromal and immune cells in health and disease
Cancer cells have been at the centre of cell metabolism research, but the metabolism of
stromal and immune cells has received less attention. Nonetheless, these cells influence the …
stromal and immune cells has received less attention. Nonetheless, these cells influence the …
Microglia in the retina: roles in development, maturity, and disease
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
retina. Recent evidence indicates that microglia play significant functional roles in the retina …