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P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
Novel Th17 lymphocyte populations, Th17. 1 and PD1+ Th17, are increased in Takayasu arteritis, and both Th17 and Th17. 1 sub-populations associate with active …
K Singh, U Rathore, MK Rai, MR Behera… - Journal of …, 2022 - Taylor & Francis
Purpose We evaluated T helper lymphocyte profile, including novel Th17 subsets Th17. 1
(secrete IFN-γ, associate with corticosteroid resistance) and PD1+ Th17 (secrete TGF-β1 …
(secrete IFN-γ, associate with corticosteroid resistance) and PD1+ Th17 (secrete TGF-β1 …
Increased interleukin-17 and glucocorticoid receptor-β expression in interstitial lung diseases and corticosteroid insensitivity
CY Lo, CH Wang, CW Wang, CJ Chen… - Frontiers in …, 2022 - frontiersin.org
Background Treatment responsiveness to corticosteroids is excellent for cryptogenic
organizing pneumonia (COP) and sarcoidosis, but suboptimal for idiopathic pulmonary …
organizing pneumonia (COP) and sarcoidosis, but suboptimal for idiopathic pulmonary …
Tacrolimus induces remission in refractory and relapsing lupus nephritis by decreasing P-glycoprotein expression and function on peripheral blood lymphocytes
S Edavalath, MK Rai, V Gupta, R Mishra… - Rheumatology …, 2022 - Springer
Abstract P-glycoprotein (P-gp)-mediated efflux of corticosteroids (CS) may contribute to
treatment unresponsiveness in Lupus Nephritis (LN) patients. Tacrolimus is a P-gp inhibitor …
treatment unresponsiveness in Lupus Nephritis (LN) patients. Tacrolimus is a P-gp inhibitor …
Molecular characterization and functional analysis of multidrug resistance-associated genes of Pinewood nematode (Bursaphelenchus xylophilus) for nematicides
X Hao, B Wang, J Chen, B Wang, J Xu, J Pan… - Pesticide Biochemistry …, 2021 - Elsevier
Bursaphelenchus xylophilus (Pinewood nematode, PWN) is the causative agent of pine wilt
disease (PWD) which caused serious threat to pine forests in the world, especially in East …
disease (PWD) which caused serious threat to pine forests in the world, especially in East …
Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in …
F Pan, Y Li, Y Lu - BMC Complementary Medicine and Therapies, 2022 - Springer
Background P-glycoprotein (P-gp)-mediated steroid resistance (SR) has been suggested to
play a significant role in lupus nephritis (LN) treatment failure. Panax notoginseng saponins …
play a significant role in lupus nephritis (LN) treatment failure. Panax notoginseng saponins …
Role of P-gp and HDAC2 and their Reciprocal Relationship in Uncontrolled Asthma
Introduction: Resistance to corticosteroid is an essential mechanism in uncontrolled asthma
as the corticosteroid is the mainstay of therapy. There are recent reports that epigenetic …
as the corticosteroid is the mainstay of therapy. There are recent reports that epigenetic …
[HTML][HTML] Значение экспрессии гена ABCB1 у детей с идиопатическим нефротическим синдромом
СЛ Морозов, АС Воронкова, ВВ Длин - Нефрология, 2021 - cyberleninka.ru
Идиопатический нефротический синдром-является наиболее распространённой
гломерулопатией в детском возрасте. Несмотря на современные достижения в …
гломерулопатией в детском возрасте. Несмотря на современные достижения в …
P-glycoprotein and/or histone deacetylase 2 regulates steroid responsiveness in childhood nephrotic syndrome
Background: P-glycoprotein (P-gp) overexpression in peripheral blood mononuclear cells
(PBMCs) has been reported in patients with steroid-resistant nephrotic syndrome (SRNS) …
(PBMCs) has been reported in patients with steroid-resistant nephrotic syndrome (SRNS) …
Histone Deacetylase-2 Inducer Like Theophylline has a Potential to Improve Glucocorticoid Responsiveness in Severe Uncontrolled Asthma by Reducing P …
R Mishra, Z Hashim, M Gupta… - Indian Journal of …, 2022 - journals.lww.com
Background: Epigenetic factors play an essential role in regulating the action of steroids in
asthma. Steroids suppress inflammation by recruiting histone deacetylase-2 (HDAC-2) …
asthma. Steroids suppress inflammation by recruiting histone deacetylase-2 (HDAC-2) …