Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
MYD88 Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies
M Alcoceba, M García-Álvarez, A Medina… - International Journal of …, 2022 - mdpi.com
The MYD88 gene has a physiological role in the innate immune system. Somatic mutations
in MYD88, including the most common L265P, have been associated with the development …
in MYD88, including the most common L265P, have been associated with the development …
Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management
MA Gertz - American journal of hematology, 2023 - Wiley Online Library
Abstract Disease Overview Waldenström macroglobulinemia (WM) is a lymphoplasmacytic
lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include …
lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include …
New developments in the diagnosis and characterization of Waldenström's macroglobulinemia
Introduction Waldenström's macroglobulinemia (WM) is defined as a lymphoplasmacytic
lymphoma (LPL) with immunoglobulin M (IgM) monoclonal gammopathy and morphologic …
lymphoma (LPL) with immunoglobulin M (IgM) monoclonal gammopathy and morphologic …
Diagnostics in Waldenström's macroglobulinemia: a consensus statement of the European Consortium for Waldenström's Macroglobulinemia
The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated
lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease …
lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease …
Transcriptome analysis of diffuse large b-cell lymphoma cells inducibly expressing MyD88 L265P mutation identifies upregulated CD44, LGALS3, NFKBIZ, and BATF …
During innate immune responses, myeloid differentiation primary response 88 (MyD88)
functions as a critical signaling adaptor protein integrating stimuli from toll-like receptors …
functions as a critical signaling adaptor protein integrating stimuli from toll-like receptors …
An aged/autoimmune B-cell program defines the early transformation of extranodal lymphomas
A third of patients with diffuse large B-cell lymphoma (DLBCL) present with extranodal
dissemination, which is associated with inferior clinical outcomes. MYD88 L265P is a …
dissemination, which is associated with inferior clinical outcomes. MYD88 L265P is a …
Targeting the immune microenvironment in Waldenström macroglobulinemia via halting the CD40/CD40-ligand axis
A Sacco, V Desantis, J Celay, V Giustini… - Blood, The Journal …, 2023 - ashpublications.org
Recent investigations have improved our understanding of the molecular aberrations
supporting Waldenström macroglobulinemia (WM) biology; however, whether the immune …
supporting Waldenström macroglobulinemia (WM) biology; however, whether the immune …
Mouse models of diffuse large B cell lymphoma
A Tabatabai, A Arora, S Höfmann, M Jauch… - Frontiers in …, 2023 - frontiersin.org
Diffuse large B cell lymphoma (DLBCL) is a genetically highly heterogeneous disease. Yet,
to date, the vast majority of patients receive standardized frontline chemo-immune-therapy …
to date, the vast majority of patients receive standardized frontline chemo-immune-therapy …
Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined …
DF Moreno, M López‐Guerra, S Paz… - British Journal of …, 2023 - Wiley Online Library
Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in
MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in …
MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in …