Metabolomics in infectious diseases and drug discovery

V Tounta, Y Liu, A Cheyne, G Larrouy-Maumus - Molecular omics, 2021 - pubs.rsc.org
Metabolomics has emerged as an invaluable tool that can be used along with genomics,
transcriptomics and proteomics to understand host–pathogen interactions at small-molecule …

Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy

DPS Chang, XL Guan - Metabolites, 2021 - mdpi.com
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly
successful intracellular pathogen with the ability to withstand harsh conditions and reside …

Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery

D Kathayat, BC VanderVen - Trends in Microbiology, 2024 - cell.com
Mycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the
stressful and nutritionally constrained environments in these cells. Exploiting these …

[HTML][HTML] Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites

H Wang, LPS de Carvalho - Current Opinion in Chemical Biology, 2023 - Elsevier
How has metabolomics helped our understanding of infectious diseases? With the threat of
antimicrobial resistance to human health around the world, metabolomics has emerged as a …

Mycobacterial regulatory systems involved in the regulation of gene expression under respiration-inhibitory conditions

Y Oh, HN Lee, EM Ko, JA Jeong, SW Park, JI Oh - Journal of Microbiology, 2023 - Springer
Mycobacterium tuberculosis is the causative agent of tuberculosis. M. tuberculosis can
survive in a dormant state within the granuloma, avoiding the host-mounting immune attack …

Metabolomics in clinical diagnosis, prognosis, and treatment of infectious diseases

AK Azad, A Hakim, MMH Sohag, M Rahman - Metabolomics, 2023 - Elsevier
Infectious diseases are one of the major causes of death worldwide. Therefore clinical
management of infectious disease requires robust biomarkers that have diagnostic and …

[PDF][PDF] Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy. Metabolites 2021, 11, 88

DPS Chang, XL Guan - 2021 - pdfs.semanticscholar.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly
successful intracellular pathogen with the ability to withstand harsh conditions and reside …

[LIBRO][B] The Phosphodiesterase, Rv0805, Is an Unheralded Component of TB Complex Mycobacterial Physiology in and Beyond Camp Homeostasis

JR McDowell - 2021 - search.proquest.com
Phosphodiesterases (PDEs) are integral components of 3', 5'-cyclic adenosine
monophosphate (cAMP) signaling pathways by degrading cAMP to modulate the …