TGF-β signal transduction
J Massagué - Annual review of biochemistry, 1998 - annualreviews.org
The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …
TGF-β signalling from cell membrane to nucleus through SMAD proteins
CH Heldin, K Miyazono, P Ten Dijke - Nature, 1997 - nature.com
The recent identification of the SMAD family of signal transducer proteins has unravelled the
mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane …
mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane …
Signaling mechanisms of the epithelial-mesenchymal transition
DM Gonzalez, D Medici - Science signaling, 2014 - science.org
The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …
development and tissue repair. EMT also contributes to the progression of disease …
Bone morphogenetic proteins
DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …
Smad transcription factors
Smad transcription factors lie at the core of one of the most versatile cytokine signaling
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …
[HTML][HTML] Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
Smad proteins play a key role in the intracellular signalling of transforming growth factor β
(TGFβ), which elicits a large variety of cellular responses. Upon TGFβ receptor activation …
(TGFβ), which elicits a large variety of cellular responses. Upon TGFβ receptor activation …
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
LB Zimmerman, JM De Jesus-Escobar, RM Harland - Cell, 1996 - cell.com
Signals released by the Spemann organizer of the amphibian gastrula can directly induce
neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The …
neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The …
[HTML][HTML] The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
H Hayashi, S Abdollah, Y Qiu, J Cai, YY Xu… - Cell, 1997 - cell.com
TGFβ signaling is initiated when the type I receptor phosphorylates the MAD-related protein,
Smad2, on C-terminal serine residues. This leads to Smad2 association with Smad4 …
Smad2, on C-terminal serine residues. This leads to Smad2 association with Smad4 …
TGF-β family signaling in tumor suppression and cancer progression
J Seoane, RR Gomis - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
The roles of signaling pathways in bone repair and regeneration
Regenerative medicine has sparked interest in potential strategies for bone repair. Bone
defects are widespread and could be caused by trauma, congenital malformations …
defects are widespread and could be caused by trauma, congenital malformations …