Building on current explorations in chronic optical neural interfaces, it is essential to address
the risk of photothermal damage in traditional optogenetics. By focusing on calcium …

Mechanobiology helps us to decipher cell and tissue functions by looking at changes in their
mechanical properties that contribute to development, cell differentiation, physiology, and …

The mechanistic link between neural circuit activity and behavior remains unclear. While
manipulating cortical activity can bias certain behaviors and elicit artificial percepts, some …

Sensory processing in the neocortex requires both feedforward and feedback information
flow between cortical areas. In feedback processing, higher-level representations provide …

Continuous attractors are an emergent property of neural population dynamics that have
been hypothesized to encode continuous variables such as head direction and eye …

Primary sensory cortex is thought to process incoming sensory information, while decision
variables important for driving behavior are assumed to arise downstream in the processing …

The basolateral amygdala (BLA) is an evolutionarily conserved brain region, well known for
valence processing. Despite this central role, the relationship between activity of BLA …

The development of three-photon microscopy (3PM) has greatly expanded the capability of
imaging deep within biological tissues, enabling neuroscientists to visualize the structure …

Determining which features of the neural code drive behavior requires the ability to
simultaneously read out and write in neural activity patterns with high precision across many …

To investigate which activity patterns in sensory cortex are relevant for perceptual decision-
making, we combined two-photon calcium imaging and targeted two-photon optogenetics to …