Heterogeneous synthetic vesicles toward artificial cells: engineering structure and composition of membranes for multimodal functionalities

J Shin, BD Cole, T Shan, Y Jang - Biomacromolecules, 2022 - ACS Publications
The desire to develop artificial cells to imitate living cells in synthetic vesicle platforms has
continuously increased over the past few decades. In particular, heterogeneous synthetic …

Signal Transduction in Artificial Cells

X Yu, V Mukwaya, S Mann, H Dou - Small Methods, 2023 - Wiley Online Library
In recent years, significant progress has been made in the emerging field of constructing
biomimetic soft compartments with life‐like behaviors. Given that biological activities occur …

Template-free in situ encapsulation of enzymes in hollow covalent organic framework capsules for the electrochemical analysis of biomarkers

H Chao, Z Zhou, W He, M Li, X Yuan, P Su… - … Applied Materials & …, 2022 - ACS Publications
Although capsule-like materials as host carriers for enzyme encapsulation have been a hot
topic in recent years, creating an ideal microenvironment for enhanced enzymatic …

Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H2O2-Responsive Release Behavior

S Moreno, H Hübner, C Effenberg, S Boye… - …, 2022 - ACS Publications
The development of compartments for the design of cascade reactions in a local space
requires a selective spatiotemporal control. The combination of enzyme-loaded …

Artificial Organelles with Digesting Characteristics: Imitating Simplified Lysosome‐and Macrophage‐Like Functions by Trypsin‐Loaded Polymersomes

X Xu, S Moreno, S Boye, P Wang, B Voit… - Advanced …, 2023 - Wiley Online Library
Defects in cellular protein/enzyme encoding or even in organelles are responsible for many
diseases. For instance, dysfunctional lysosome or macrophage activity results in the …

Feedback-Induced and Oscillating pH Regulation of a Binary Enzyme–Polymersomes System

X Wang, S Moreno, S Boye, P Wen, K Zhang… - Chemistry of …, 2021 - ACS Publications
The stimuli-triggered regulating ability is a basic characteristic of biological systems, and it is
always cyclic in nature. To mimic this stimuli-triggered regulation process for the construction …

Probing Crowdedness of artificial organelles by clustering polymersomes for spatially controlled and pH-triggered enzymatic reactions

P Wang, S Moreno, A Janke, S Boye, D Wang… - …, 2022 - ACS Publications
Most sophisticated biological functions and features of cells are based on self-organization,
and the coordination and connection between their cell organelles determines their key …

[HTML][HTML] pH-stable polymersome as nanocarrier for post-loaded rose bengal in photodynamic therapy

K Sztandera, M Gorzkiewicz, X Wang, S Boye… - Colloids and Surfaces B …, 2022 - Elsevier
Photodynamic therapy is one of the best alternatives to chemo-, radio-or surgical therapy, as
it is noninvasive and causes no severe side effects. The mechanism of photodynamic …

Biomimetic cell structures: probing induced pH-feedback loops and pH self-monitoring in cytosol using binary enzyme-loaded polymersomes in proteinosome

K Zhang, S Moreno, X Wang, Y Zhou, S Boye… - …, 2023 - ACS Publications
Structures and functions of eukaryotic cells with an outer permeable membrane, a
cytoskeleton, functional organelles, and motility can be mimicked by giant multicompartment …

Interactions of Clay Minerals with Biomolecules and Protocells Complex Structures in the Origin of Life: A Review

Y Yan, H Yang - Advanced Functional Materials, 2024 - Wiley Online Library
The origin of life (OoL) has always been a mysterious and challenging topic that puzzles
human beings. Clay minerals have unique properties and wide distribution in early Earth …