Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
General pathways of pain sensation and the major neurotransmitters involved in pain regulation
Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …
communication. NMDARs form tetrameric complexes that consist of several homologous …
Glutamate and GABA imbalance following traumatic brain injury
Traumatic brain injury (TBI) leads to multiple short-and long-term changes in neuronal
circuits that ultimately conclude with an imbalance of cortical excitation and inhibition …
circuits that ultimately conclude with an imbalance of cortical excitation and inhibition …
Crystal structure of a heterotetrameric NMDA receptor ion channel
N-Methyl-d-aspartate (NMDA) receptors belong to the family of ionotropic glutamate
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
NMDA receptor structures reveal subunit arrangement and pore architecture
Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …
requiring binding of glycine and glutamate in combination with the relief of voltage …
Polyamines: bio-molecules with diverse functions in plant and human health and disease
Biogenic amines—polyamines (PAs), particularly putrescine, spermidine and spermine are
ubiquitous in all living cells. Their indispensable roles in many biochemical and …
ubiquitous in all living cells. Their indispensable roles in many biochemical and …
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …
nervous system and function by opening a transmembrane ion channel upon binding of …