Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Mendelian disorders and monogenic traits result from combinations of variants in 1 or a few
genes that have a large effect on the propensity for develo** a certain disease or …

Objective To optimise dementia prevention strategies, we must understand the complex
relationships between lifestyle behaviours, frailty and genetics. Methods We explored …

Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia
faces pressing challenges, such as heterogeneity, diversity, political instability, and …

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or
declining rates in North America and Europe. This scenario places unprecedented clinical …

Abstract Alzheimer's disease (AD), the most common type of dementia, is becoming a major
challenge for global health and social care. However, the current understanding of AD …

Importance Polygenic risk scores (PRSs), which aggregate the genetic effects of single-
nucleotide variants identified in genome-wide association studies (GWASs), can help …

This review is focused on several psychiatric disorders in which cognitive impairment is a
major component of the disease, influencing life quality. There are plenty of data proving that …