Alzheimer's disease: an updated overview of its genetics
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …
classified as familial and sporadic. The dominant familial or autosomal presentation …
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease
Background Alzheimer's disease is a debilitating and highly heritable neurological
condition. As such, genetic studies have sought to understand the genetic architecture of …
condition. As such, genetic studies have sought to understand the genetic architecture of …
Microglial efferocytosis: diving into the Alzheimer's disease gene pool
Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …
Early-onset Alzheimer's disease: what is missing in research?
Abstract Purpose of Review Early-onset Alzheimer's disease (EOAD), defined as
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment
Background Human genetic association studies point to immune response and lipid
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …
Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets
To provide better prevention and treatment, we need to understand the environmental and
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …
Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease
Alzheimer's disease (AD) manifests along a spectrum of cognitive deficits and levels of
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …
Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants
J Hoogmartens, R Cacace… - … & Dementia: Diagnosis …, 2021 - Wiley Online Library
Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …