Aging is a complex process with an impact on essentially all organs. Declined cellular repair
causes increased damage at genomic and proteomic levels upon aging. This can lead to …

Recent and accumulating work in experimental animal models and humans shows that diet
has a much more pervasive and prominent role than previously thought in modulating …

Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with
circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and …

Background Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported
to be involved in neuroinflammation in Alzheimer's disease and traumatic brain injury. The …

Increased life expectancy in combination with modern life style and high prevalence of
obesity are important risk factors for development of neurodegenerative diseases …

There is robust evidence that major depression (MDD) is accompanied by a low-grade
activation of the immune-inflammatory response system, which is involved in the …

Findings from epidemiological studies, biomarker measurements and animal experiments
suggest a role for aberrant immune processes in the pathogenesis of major depressive …

Polarization of microglia/macrophages toward the pro-inflammatory phenotype is an
important contributor to neuroinflammation after intracerebral hemorrhage (ICH). Dectin-1 is …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative
disorder affecting striatal neurons beginning in young adults with loss of muscle …