Noncovalent interactions, which usually feature tunable strength, reversibility, and
environmental adaptability, have been recognized as driving forces in a variety of biological …

It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Many cellular proteins demix spontaneously from solution to form liquid condensates. These
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …

Molecular recognition, binding and catalysis are often mediated by non-covalent interactions
involving aromatic functional groups. Although the relative complexity of these so-called π …

The σ-hole and π-hole are the regions with positive surface electrostatic potential on the
molecule entity; the former specifically refers to the positive region of a molecular entity …

Noncovalent interactions are essential for the existence of solid and liquid phases. 1, 2
Traditionally touted as weak forces, quantification of these interactions, which govern the …

Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

Catalysis by neutral, organic, small molecules capable of binding and activating substrates
solely via noncovalent interactions—particularly H-bonding—has emerged as an important …

Cation–π interactions are common in nature, especially in organisms. Their profound
influences in chemistry, physics, and biology have been continuously investigated since …

Catalysis by small molecules (≤ 1000 Da, 10− 9 m) that are capable of binding and
activating substrates through attractive, noncovalent interactions has emerged as an …