T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have
shown remarkable success in treating patients with hematologic malignancies and …

T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour
antigens have led to high complete response rates in patients with haematologic …

The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

In the past decade, the study of mechanisms of cancer immunity has seen a prominent
boom, which paralleled the increased amount of research on the clinical efficacy of immune …

Melanoma is one of the most aggressive and progressive skin cancers. It develops from
normal pigment-producing cells known as melanocytes, so it is important to know the …

Highlights•AMPK is activated by immune and environmental stimuli in T cells.•AMPK
regulates T cell fuel usage in response to nutrient availability.•AMPK control of metabolism …

Current therapies against cancer utilize the patient's immune system for tumor eradication.
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …

Substantial evolution in cancer therapy has been witnessed lately, steering mainly towards
immunotherapeutic approaches, replacing or in combination with classical therapies …

Background/Aims: Recent studies have shown that circulating microRNAs (miRNAs) are
emerging as promising biomarkers for cardiovascular diseases. This study aimed to …

Cancer cells grow in an environment comprised of multiple components that support tumor
growth and contribute to therapy resistance. Major cell types in the tumor microenvironment …