This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …

Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Patients with heart failure experience a number of changes in the electrical function of the
heart that predispose to potentially lethal cardiac arrhythmias. Action potential prolongation …

1. Introduction Administration Heart Failure Trial) and other trials suggest that death is
disproportionately sudden in patients with Over 2 million Americans suffer from heart failure …

Cardiomyocyte function depends on coordinated movements of calcium into and out of the
cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling …

The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are
invaginations of the surface membrane. Recent studies have suggested that the structure …

Ca is critical in both the electrical and mechanical properties of cardiac myocytes, and much
is known about ionic currents and the normal excitation-contraction coupling process. In …

Loss of cardiac myocytes in heart failure is thought to occur largely through an apoptotic
process. Here we show that heart failure can also be precipitated through myocyte necrosis …

Calcium Cycling in Congestive Heart Failure - ScienceDirect Skip to main contentSkip to article
Elsevier logo Journals & Books Search RegisterSign in View PDF Download full issue Search …