Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

World population has been continuously increasing and progressively aging. Aging is
characterized by a complex and intraindividual process associated with nine major cellular …

Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …

Telomeres protect the integrity of information-carrying DNA by serving as caps on the
terminal portions of chromosomes. Telomere length decreases with aging, and this …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

Telomere length shortens with age. Progressive shortening of telomeres leads to
senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health …

T cell senescence is thought to contribute to immune function decline, but the pathways that
mediate senescence in these cells are not clear. Here, we evaluated T cell populations from …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Senescent T-cells accumulate with age, lowering the naïve T-cell repertoire and increasing
host infection risk. As this response is likely to be influenced by certain lifestyle factors, we …