Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury

H Khan, K Sharma, A Kumar, A Kaur, TG Singh - Inflammation Research, 2022 - Springer
Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …

Dysbiosis and Alzheimer's disease: a role for chronic stress?

VK Sharma, TG Singh, N Garg, S Dhiman, S Gupta… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is an incurable, neuropsychiatric, pathological condition that
deteriorates the worth of geriatric lives. AD is characterized by aggregated senile amyloid …

[HTML][HTML] Animal models of diabetic microvascular complications: Relevance to clinical features

R Singh, SA Farooq, A Mannan, TG Singh… - Biomedicine & …, 2022 - Elsevier
Diabetes has become more common in recent years worldwide, and this growth is projected
to continue in the future. The primary concern with diabetes is develo** various …

Advancements and challenges of fuel cell integration in electric vehicles: A comprehensive analysis

M Singh, MK Singla, M Safaraliev, K Singh… - International Journal of …, 2024 - Elsevier
Fuel cell technology emerges as a promising green solution, offering mitigation to global
warming, air pollution, and energy crises. This eco-friendly approach is witnessing a surge …

Peroxisome proliferator-activated receptor-gamma (PPAR-ɣ): molecular effects and its importance as a novel therapeutic target for cerebral ischemic injury

A Mannan, N Garg, TG Singh, HK Kang - Neurochemical Research, 2021 - Springer
Cerebral ischemic injury is a leading cause of death and long-term disability throughout the
world. Peroxisome proliferator-activated receptor gamma (PPAR-ɣ) is a ligand-activated …

Emerging targets for modulation of immune response and inflammation in stroke

K Thapa, K Shivam, H Khan, A Kaur, K Dua… - Neurochemical …, 2023 - Springer
The inflammatory and immunological responses play a significant role after stroke. The
innate immune activation stimulated by microglia during stroke results in the migration of …

Identification of drug-drug interactions using chemical interactions

L Chen, C Chu, YH Zhang, M Zheng… - Current …, 2017 - ingentaconnect.com
Background: One drug can affect the activity of another when they are administered
together, which can cause adverse drug reactions or sometimes improve therapeutic effects …

Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis

S Vishwakarma, S Singh, TG Singh - Molecular Biology Reports, 2022 - Springer
Epileptic seizure-induced brain injuries include activation of neuroimmune response with
activation of microglia, astrocytes cells releasing neurotoxic inflammatory mediators …

Neuro-inflammation, blood-brain barrier, seizures and autism

TC Theoharides, B Zhang - Journal of neuroinflammation, 2011 - Springer
Abstract Many children with Autism Spectrum Diseases (ASD) present with seizure activity,
but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation …

Evidence for the involvement of the dopaminergic system in seizure and oxidative damage induced by tramadol

B Bameri, F Shaki, N Ahangar… - International …, 2018 - journals.sagepub.com
Tramadol (TR) is a synthetic analgesic drug with central function that can induce seizures
even at therapeutic doses. The exact mechanism of TR effect on seizure generation is not …