Crucial as molecular sensors for many vital physiological processes, seven-transmembrane
domain G protein-coupled receptors (GPCRs) comprise the largest family of proteins …

The first member and eponym of the rhodopsin family was identified in the 1930s as the
visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a …

Structural studies of G protein-coupled receptors (GPCRs) gave insights into molecular
mechanisms of their action and contributed significantly to molecular pharmacology. This is …

Knowledge about retinal photoreceptor signal transduction and the visual cycle required for
normal eyesight has increased exponentially over the past decade. Substantial progress in …

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins,
participate in the regulation of many physiological functions and are the targets of …

Whereas membrane proteins make up∼ 23% of the human proteome, it is estimated that
membrane proteins constitute more than 60% of current drug targets. With membrane …

G protein-coupled receptors (GPCRS) represent a class of integral membrane proteins
involved in many biological processes and pathologies. Fifty percent of all modern drugs …

The current study investigates the cellular events which trigger activation of proapoptotic Bcl-
2-associated× protein (Bax) in retinal cell death induced by all-trans-retinal (atRAL). Cellular …

Recently, the atomic structures of invertebrate rhodopsin, β 1-adrenergic and β 2-adrenergic
receptors and the A 2A-adenosine receptor have been solved via X-ray crystallography. The …

Rhodopsin is a cilia-specific GPCR essential for vision. Rhodopsin mislocalization is
associated with blinding diseases called retinal ciliopathies. The mechanism by which …