The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis
(TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film …

Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the
gold standard autograft) and its main clinically approved alternative—hollow nerve guidance …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …

The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for
the survival of sensory and sympathetic neurons during development. However in the adult …

Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …

Chronic neurodegenerative diseases represent major unmet needs for therapeutic
interventions. Recently, the neurocentric view of brain function and disease has been …

Peptides can serve as versatile cancer-targeting ligands and have been used for clinically
relevant applications such as cancer imaging and therapy. A current and long-standing …