Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …
environment or partition cells into distinct compartments. These membranes are lipid …
Beyond autophagy: LC3-associated phagocytosis and endocytosis
Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …
Structural basis of NINJ1-mediated plasma membrane rupture in cell death
M Degen, JC Santos, K Pluhackova, G Cebrero… - Nature, 2023 - nature.com
Eukaryotic cells can undergo different forms of programmed cell death, many of which
culminate in plasma membrane rupture as the defining terminal event,,,,,–. Plasma …
culminate in plasma membrane rupture as the defining terminal event,,,,,–. Plasma …
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …
among the most frequent causes of disability and death worldwide. Current treatment …
RBG motif bridge-like lipid transport proteins: structure, functions, and open questions
The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …
The apoptosis paradox in cancer
O Morana, W Wood, CD Gregory - International journal of molecular …, 2022 - mdpi.com
Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …
Phagocytosis: our current understanding of a universal biological process
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …
in diameter, including microorganisms, foreign substances, and apoptotic cells …
Apoptotic bodies: particular extracellular vesicles involved in intercellular communication
M Battistelli, E Falcieri - Advances in Medical Biochemistry …, 2021 - api.taylorfrancis.com
18.1. 1 Extracellular Vesicles The direct contact between two or more cells and the
interaction between the ligand and the receptor have been considered, for a long time, the …
interaction between the ligand and the receptor have been considered, for a long time, the …
Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy
Activation of scramblases is one of the mechanisms that regulates the exposure of
phosphatidylserine to the cell surface, a process that plays an important role in tumour …
phosphatidylserine to the cell surface, a process that plays an important role in tumour …