Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Beyond autophagy: LC3-associated phagocytosis and endocytosis

C Peña-Martinez, AD Rickman, BL Heckmann - Science advances, 2022 - science.org
Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Structural basis of NINJ1-mediated plasma membrane rupture in cell death

M Degen, JC Santos, K Pluhackova, G Cebrero… - Nature, 2023 - nature.com
Eukaryotic cells can undergo different forms of programmed cell death, many of which
culminate in plasma membrane rupture as the defining terminal event,,,,,–. Plasma …

The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis

Z Lin, J Liu, F Long, R Kang, G Kroemer, D Tang… - Nature …, 2022 - nature.com
Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

RBG motif bridge-like lipid transport proteins: structure, functions, and open questions

M Hanna, A Guillén-Samander… - Annual Review of Cell …, 2023 - annualreviews.org
The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

The apoptosis paradox in cancer

O Morana, W Wood, CD Gregory - International journal of molecular …, 2022 - mdpi.com
Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Phagocytosis: our current understanding of a universal biological process

E Uribe-Querol, C Rosales - Frontiers in immunology, 2020 - frontiersin.org
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …

Apoptotic bodies: particular extracellular vesicles involved in intercellular communication

M Battistelli, E Falcieri - Advances in Medical Biochemistry …, 2021 - api.taylorfrancis.com
18.1. 1 Extracellular Vesicles The direct contact between two or more cells and the
interaction between the ligand and the receptor have been considered, for a long time, the …

Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy

Y Chen, Y Huang, Q Li, Z Luo, Z Zhang… - Nature …, 2023 - nature.com
Activation of scramblases is one of the mechanisms that regulates the exposure of
phosphatidylserine to the cell surface, a process that plays an important role in tumour …