Dopamine receptors–IUPHAR R eview 13
The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
Role of oxidative stress and antioxidants in acquired inner ear disorders
Oxygen metabolism in the mitochondria is essential for biological activity, and reactive
oxygen species (ROS) are produced simultaneously in the cell. Once an imbalance between …
oxygen species (ROS) are produced simultaneously in the cell. Once an imbalance between …
Genetic architecture distinguishes tinnitus from hearing loss
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …
TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti
M Kaiser, TH Lüdtke, L Deuper, C Rudat… - Nature …, 2022 - nature.com
The auditory function of the mammalian cochlea relies on two types of mechanosensory hair
cells and various non-sensory supporting cells. Recent studies identified the transcription …
cells and various non-sensory supporting cells. Recent studies identified the transcription …
Efferent inhibition of the cochlea
PA Fuchs, AM Lauer - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Cholinergic efferent neurons originating in the brainstem innervate the acoustico-lateralis
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit …
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit …
Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers
JS Wu, E Yi, M Manca, H Javaid, AM Lauer… - Elife, 2020 - elifesciences.org
Lateral olivocochlear (LOC) efferent neurons modulate auditory nerve fiber (ANF) activity
using a large repertoire of neurotransmitters, including dopamine (DA) and acetylcholine …
using a large repertoire of neurotransmitters, including dopamine (DA) and acetylcholine …
Dopaminergic effects on in vitro osteogenesis
Multiple growth factors (eg, BMP2, TGF-β1, FGF2) and isolated genes have been shown to
improve osteoblastic proliferation and mineralization, advancing bone tissue engineering …
improve osteoblastic proliferation and mineralization, advancing bone tissue engineering …
[HTML][HTML] The afferent signaling complex: regulation of type I spiral ganglion neuron responses in the auditory periphery
The spiral ganglion neurons (SGNs) are the first action potential generating neurons in the
auditory pathway. The type I SGNs contact the sensory inner hair cells via their peripheral …
auditory pathway. The type I SGNs contact the sensory inner hair cells via their peripheral …
Electron microscopic reconstruction of neural circuitry in the cochlea
Recent studies reveal great diversity in the structure, function, and efferent innervation of
afferent synaptic connections between the cochlear inner hair cells (IHCs) and spiral …
afferent synaptic connections between the cochlear inner hair cells (IHCs) and spiral …
Central circuitry and function of the cochlear efferent systems
GE Romero, LO Trussell - Hearing research, 2022 - Elsevier
The cochlear efferent system comprises multiple populations of brainstem neurons whose
axons project to the cochlea, and whose responses to acoustic stimuli lead to regulation of …
axons project to the cochlea, and whose responses to acoustic stimuli lead to regulation of …