Vascular endothelial (VE)-cadherin, an endothelium-specific adhesion protein, is found in
the junctions between endothelial cells (ECs). It's crucial to maintain the homogeneity of …

Ischemic stroke is currently the second leading cause of mortality worldwide, with limited
treatment options available. As resident immune cells, microglia promptly respond to …

Patients with neovascular AMD (nAMD) suffer vision loss from destructive angiogenesis,
termed choroidal neovascularization (CNV). Macrophages are found in CNV lesions from …

Anti–vascular endothelial growth factor therapy has had a substantial impact on the
treatment of choroidal neovascularization (CNV) in patients with neovascular age-related …

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal
fibroblasts. Recent studies have highlighted the role of glycolysis in this process …

Pathological neovascularization is a pivotal biological process in wet age-related macular
degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy …

Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases.
Inflammatory injury and aberrant repair processes contribute to the development of kidney …

Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitor (SGLT2i) is a novel class of anti-
diabetic drug, which has displayed a promising benefit for non-alcoholic fatty liver disease …

Globally, age-related macular degeneration (AMD) is the leading cause of irreversible visual
impairment. Up to 80% of severe vision loss is caused by AMD, which is characterized by …

Background Neovascular age-related macular degeneration causes vision loss from
destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1−/− mice …