The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Coronary artery disease is a major underlying etiology for heart failure. The role of coronary
microvascular disease, and endothelial dysfunction, in the pathophysiology of heart failure is …

Most animals experience some degree of hypoxia and hypothermia during the course of
their natural life history either as a consequence of ambient 'exposure'per se or through …

Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

Pathological conditions linked to imbalances in oxygen supply and demand (for example,
ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium …

The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

Objectives: We investigated changes in Na+ currents (INa) in permanent (or chronic) atrial
fibrillation (AF) and the effects of INainhibition using ranolazine (Ran) on arrhythmias and …