Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Fucose is a deoxyhexose that is present in a wide variety of organisms. In mammals, fucose-
containing glycans have important roles in blood transfusion reactions, selectin-mediated …

Cell surface proteins are major targets of biomedical research due to their utility as cellular
markers and their extracellular accessibility for pharmacological intervention. However …

Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes,
express high levels of telomerase activity, and express cell surface markers that characterize …

This report describes the establishment directly from normal preimplantation mouse
embryos of a cell line that forms teratocarcinomas when injected into mice. The pluripotency …

Murine embryonic stem (ES) cells are pluripotent cell lines established directly from the early
embryo1, 2 which can contribute differentiated progeny to all adult tissues, including the …

Human pluripotent stem cells would be invaluable for in vitro studies of aspects of human
embryogenesis. With the goal of establishing pluripotent stem cell lines, gonadal ridges and …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in
vitro while maintaining the potential to differentiate into derivatives of all three embryonic …

Steel factor (SF) and LIF (leukemia inhibitory factor) synergistically promote the proliferation
and survival of mouse primordial germ cells (PGCs), but only for a limited time period in …