The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …

Cancer stem cells (CSCs) as a small subpopulation in tumor bulk are believed to initiate
tumor formation and are responsible for the resistance to cancer therapy. The proliferation …

Glioblastoma (GBM) is the most common and malignant astrocytic glioma, accounting for
about 90% of all brain tumors with poor prognosis. Despite recent advances in …

Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …

Cancer stem cells (CSCs) are a type of stem cell that possesses not only the intrinsic
abilities of stem cells but also the properties of cancer cells. Therefore, CSCs are known to …

Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …

The serine/threonine kinase Akt is a major player in the phosphoinositide 3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, and its modulation …

Melanoma is the most aggressive and fatal type of skin cancer due to being highly
proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA) are ancient drugs with …

Glioblastoma is the most common and lethal primary brain malignancy. Despite major
investments in research into glioblastoma biology and drug development, treatment remains …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …