Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …

Thiyl radicals have been used by nature in a broad range of biochemical processes. For
instance, thiol residues play an important role in many enzymatic processes as illustrated by …

The amide functionality is found in a wide variety of biological and synthetic structures such
as proteins, polymers, pesticides and pharmaceuticals. Due to the fact that synthetic amides …

The indanyl core is ubiquitous in a large variety of drugs and natural products. Importantly,
the ever-increasing demand for chiral catalysts bearing this scaffold calls for state of the art …

With recent outbreaks of COVID-19 and Ebola, health and healthcare have once more
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …

Lipase from Candida antarctica (CAL-A or CAL-B) can be considered the most efficient and
widely used enzyme in aminolysis and ammonolysis reactions, as well as for esterification …

A unique lipase (SpL) from Sphingomonas sp. HXN-200 was discovered as the first
intracellular enzyme for the aminolysis of ester or acid to produce amide. Reactions of a …

Resolution methods of racemic or enriched mixtures are continuously exploited and
developed, particularly to obtain both enantiomers of chiral compounds. This compilation …

Raney metals were studied as heterogeneous catalysts for racemization and dynamic
kinetic resolution (DKR) of chiral amines, as an alternative to metals like palladium or …

The association of lipase-catalyzed enzymatic resolution with in situ racemization mediated
with the thiyl radical enables the dynamic kinetic resolution of non-benzylic amines. It leads …