Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …

Gene expression is regulated by transcription factors that work together to read cis-
regulatory DNA sequences. The 'cis-regulatory code'—how cells interpret DNA sequences …

Engineering the genetic code of an organism has been proposed to provide a firewall from
natural ecosystems by preventing viral infections and gene transfer,,,,–. However, numerous …

Many high-throughput experimental technologies have been developed to assess the
effects of large numbers of mutations (variation) on phenotypes. However, designing …

Plasmonic optical biosensors for the analysis of nucleic acids have drawn a great deal of
interest in nanomedicine because of their capability to overcome major limitations of …

This article is a mini-review that provides a general overview for next-generation sequencing
(NGS) and introduces one of the most popular NGS applications, whole genome …

Genetically engineered mouse models (GEMMs) help us to understand human pathologies
and develop new therapies, yet faithfully recapitulating human diseases in mice is …

Leading researchers working on synthetic biology and its applications gathered at the
University of Edinburgh in May 2018 to discuss the latest challenges and opportunities in the …

Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

The completion of the Human Genome Project (HGP) in 2001 opened the floodgates to a
deeper understanding of medicine. There are dozens of HGP-like projects which involve …