Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …

The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

Triple-negative breast cancer (TNBC) shows a higher response rate to systemic therapy
compared with other breast cancer subtypes. However, the tumor differentiation of TNBC is …

Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available.
However, merely inhibiting the glycolysis is insufficient for the eradication of cancer cells …

Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …